Protein: P10275

Uniprot: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169, 187 GO:0034641 cellular nitrogen compound metabolic process 35 4.22e-144 6.90e-18
Module ID (MoonGO) GO ID (BP) GO Name
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
195 GO:0006468 protein phosphorylation
195 GO:0010468 regulation of gene expression
195 GO:0051246 regulation of protein metabolic process
195 GO:0007165 signal transduction
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
429 GO:0016070 RNA metabolic process
429 GO:0034645 cellular macromolecule biosynthetic process
429 GO:0044271 cellular nitrogen compound biosynthetic process
429 GO:0019538 protein metabolic process
429 GO:0010468 regulation of gene expression
429 GO:0010556 regulation of macromolecule biosynthetic process
429 GO:0019219 regulation of nucleobase-containing compound metabolic process
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
Module ID (MoonGO) GO ID (CC) GO Name
29 GO:0005634 nucleus
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
155 GO:0005634 nucleus
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
169 GO:0005654 nucleoplasm
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
195 GO:0005829 cytosol
195 GO:0005634 nucleus
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
357 GO:0005654 nucleoplasm
394 GO:0005654 nucleoplasm
429 GO:0070013 intracellular organelle lumen
429 GO:0005634 nucleus
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0001701 in utero embryonic development IEA
GO:0003073 regulation of systemic arterial blood pressure IEA
GO:0003382 epithelial cell morphogenesis IEA
GO:0006351 transcription, DNA-templated IDA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0006810 transport TAS
GO:0007165 signal transduction TAS
GO:0007267 cell-cell signaling TAS
GO:0007283 spermatogenesis IEA
GO:0007338 single fertilization IEA
GO:0007548 sex differentiation NAS
GO:0008283 cell proliferation NAS
GO:0008284 positive regulation of cell proliferation IDA
GO:0008285 negative regulation of cell proliferation IMP
GO:0010628 positive regulation of gene expression IMP
GO:0016049 cell growth NAS
GO:0016579 protein deubiquitination TAS
GO:0019102 male somatic sex determination IEA
GO:0030521 androgen receptor signaling pathway IDA
GO:0030522 intracellular receptor signaling pathway IDA
GO:0030850 prostate gland development NAS
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
GO:0033327 Leydig cell differentiation IEA
GO:0035264 multicellular organism growth IEA
GO:0042327 positive regulation of phosphorylation IMP
GO:0043410 positive regulation of MAPK cascade IEA
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
GO:0045597 positive regulation of cell differentiation IMP
GO:0045720 negative regulation of integrin biosynthetic process IDA
GO:0045726 positive regulation of integrin biosynthetic process IDA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0045945 positive regulation of transcription from RNA polymerase III promoter IDA
GO:0048638 regulation of developmental growth IEA
GO:0048645 animal organ formation IEA
GO:0048808 male genitalia morphogenesis IEA
GO:0050680 negative regulation of epithelial cell proliferation IEA
GO:0050790 regulation of catalytic activity IEA
GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
GO:0051259 protein oligomerization IDA
GO:0060520 activation of prostate induction by androgen receptor signaling pathway IEA
GO:0060571 morphogenesis of an epithelial fold IEA
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis IEA
GO:0060736 prostate gland growth IEA
GO:0060740 prostate gland epithelium morphogenesis IEA
GO:0060742 epithelial cell differentiation involved in prostate gland development IEA
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis IEA
GO:0060749 mammary gland alveolus development IEA
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development IEA
GO:0071383 cellular response to steroid hormone stimulus IMP
GO:0071394 cellular response to testosterone stimulus IEA
GO:0072520 seminiferous tubule development IEA
GO:1903076 regulation of protein localization to plasma membrane IDA
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
GO:0016607 nuclear speck IDA
GO:0043234 protein complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0000790 nuclear chromatin GO:0005886 plasma membrane 1.05e-21 5.03e-79
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005886 plasma membrane GO:0016607 nuclear speck 2.37e-16 9.27e-101
Interactor Also a MoonDB EMF protein
ARI5A_HUMAN No
FHL2_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
GRB7_HUMAN No
KAT5_HUMAN No
BLK_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
PAX6_HUMAN No
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
TS101_HUMAN Yes: Q99816 (MoonDB)
LCOR_HUMAN No
G45IP_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
TEBP_HUMAN No
HSP7C_HUMAN Yes: P11142 (MoonDB)
HCK_HUMAN No
DEN5A_HUMAN No
SHC3_HUMAN No
SMRD1_HUMAN No
DAXX_HUMAN No
MAGAB_HUMAN Yes: P43364 (MoonDB)
P53_HUMAN Yes: P04637 (MoonDB)
HSP76_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
TENS4_HUMAN No
NSD1_HUMAN Yes: Q96L73 (MoonDB)
HS90A_HUMAN Yes: P07900 (MoonDB)
UBC9_HUMAN Yes: P63279 (MoonDB)
RNF4_HUMAN No
ARIP4_HUMAN No
GRAP2_HUMAN No
RACK1_HUMAN No
PIAS1_HUMAN No
PIAS2_HUMAN No
SOCS3_HUMAN No
YES_HUMAN No
BRCA1_HUMAN No
SHC1_HUMAN No
SMAD3_HUMAN Yes: P84022 (MoonDB)
G3P_HUMAN Yes: P04406 (MoonDB)
SMAD1_HUMAN Yes: Q15797 (MoonDB)
ABL1_HUMAN Yes: P00519 (MoonDB)
SRC_HUMAN Yes: P12931 (MoonDB)
PLCG1_HUMAN Yes: P19174 (MoonDB)
CRK_HUMAN Yes: P46108 (MoonDB)
JUND_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
LCK_HUMAN No
PTK6_HUMAN No
P85B_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
ACTB_HUMAN No
BLNK_HUMAN No
BTK_HUMAN No
CAV1_HUMAN No
CBP_HUMAN No
CDK6_HUMAN Yes: Q00534 (MoonDB)
COX5B_HUMAN No
CSN2_HUMAN No
CTDS2_HUMAN No
CTNB1_HUMAN No
DCAF6_HUMAN No
DCC_HUMAN No
DDC_HUMAN No
ETS1_HUMAN Yes: P14921 (MoonDB)
FES_HUMAN No
FGR_HUMAN No
FOXO1_HUMAN No
GAK_HUMAN No
GELS_HUMAN No
GRIP1_HUMAN No
HDAC1_HUMAN No
HSH2D_HUMAN No
JHD2C_HUMAN No
KAT7_HUMAN No
KIF1A_HUMAN No
KIFA3_HUMAN No
KLK3_HUMAN No
KSYK_HUMAN Yes: P43405 (MoonDB)
LATS2_HUMAN No
LYN_HUMAN No
MATK_HUMAN No
MD12L_HUMAN No
MDN1_HUMAN No
MED24_HUMAN No
MLH3_HUMAN No
NAL10_HUMAN No
NCOA1_HUMAN No
NCOA2_HUMAN No
NCOA3_HUMAN Yes: Q9Y6Q9 (MoonDB)
NCOA4_HUMAN No
NCOA6_HUMAN No
NCOR1_HUMAN No
NCOR2_HUMAN No
NDE1_HUMAN No
NR0B2_HUMAN No
NR2C1_HUMAN No
NR2C2_HUMAN No
NSD2_HUMAN No
PAK6_HUMAN No
PARK7_HUMAN No
PIAS3_HUMAN No
PLCG2_HUMAN Yes: P16885 (MoonDB)
PTN11_HUMAN Yes: Q06124 (MoonDB)
RAD9A_HUMAN No
RANB9_HUMAN No
RAN_HUMAN No
RASA1_HUMAN No
RB_HUMAN No
REPS2_HUMAN No
RNF14_HUMAN No
SH21A_HUMAN No
SH21B_HUMAN No
SH22A_HUMAN Yes: Q9NP31 (MoonDB)
SH2D3_HUMAN No
SHB_HUMAN No
SHC4_HUMAN No
SHE_HUMAN No
SHIP2_HUMAN No
SMCA2_HUMAN No
SMCA4_HUMAN No
SOCS6_HUMAN No
SPOP_HUMAN No
SRY_HUMAN No
STAP1_HUMAN No
STIP1_HUMAN No
SVIL_HUMAN No
TAF1_HUMAN No
TENS1_HUMAN No
TGFI1_HUMAN No
TMF1_HUMAN No
UXT_HUMAN No
VAV2_HUMAN Yes: P52735 (MoonDB)
VAV3_HUMAN No
VAV_HUMAN No
ZBTB1_HUMAN No
ZMIZ1_HUMAN No
ZMIZ2_HUMAN No
ZN363_HUMAN No
ZN451_HUMAN No
PMID Article Title
1303262 A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome.
1307250 Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome.
1316540 Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.
1424203 Point mutations detected in the androgen receptor gene of three men with partial androgen insensitivity syndrome.
1426313 A unique point mutation in the androgen receptor gene in a family with complete androgen insensitivity syndrome.
1430233 Mutations in the ligand-binding domain of the androgen receptor gene cluster in two regions of the gene.
1458719 Androgen resistance due to mutation of the androgen receptor.
1464650 Immunoreactive androgen receptor expression in subjects with androgen resistance.
1480178 Single base mutations in the human androgen receptor gene causing complete androgen insensitivity: rapid detection by a modified denaturing gradient gel electrophoresis technique.
1487249 Point mutation in the steroid-binding domain of the androgen receptor gene in a family with complete androgen insensitivity syndrome (CAIS).
1561105 Trinucleotide repeat polymorphism in the androgen receptor gene (AR).
1562539 The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
1569163 A single amino acid substitution (Met-786-->Val) in the steroid-binding domain of human androgen receptor leads to complete androgen insensitivity syndrome.
1609793 Replacement of arginine 773 by cysteine or histidine in the human androgen receptor causes complete androgen insensitivity with different receptor phenotypes.
1631125 Androgen receptor gene mutations in human prostate cancer.
1775137 Substitution of aspartic acid-686 by histidine or asparagine in the human androgen receptor leads to a functionally inactive protein with altered hormone-binding characteristics.
1856263 Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg-->Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function.
1999491 A mutation in the DNA-binding domain of the androgen receptor gene causes complete testicular feminization in a patient with receptor-positive androgen resistance.
2010552 Molecular basis of androgen resistance in a family with a qualitative abnormality of the androgen receptor and responsive to high-dose androgen therapy.
2062380 Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.
2082179 Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity.
2260966 A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens.
2293020 Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance.
2342476 Specific region in hormone binding domain is essential for hormone binding and trans-activation by human androgen receptor.
2546571 Structural organization of the human androgen receptor gene.
2594783 Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.
2911578 Characterization and expression of a cDNA encoding the human androgen receptor.
2917688 The N-terminal domain of the human androgen receptor is encoded by one, large exon.
3174628 Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.
3216866 The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate.
3353726 Molecular cloning of human and rat complementary DNA encoding androgen receptors.
3353727 Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
3377788 Cloning, structure and expression of a cDNA encoding the human androgen receptor.
7511268 Androgen receptor gene mutations and p53 gene analysis in advanced prostate cancer.
7537149 Leu-676-Pro mutation of the androgen receptor causes complete androgen insensitivity syndrome in a large Hutterite kindred.
7581399 Human androgen insensitivity due to point mutations encoding amino acid substitutions in the androgen receptor steroid-binding domain.
7591265 Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding.
7626493 Androgen receptor mutations.
7633398 Characterization of alternative amino acid substitutions at arginine 830 of the androgen receptor that cause complete androgen insensitivity in three families.
7641413 Genetic counselling in complete androgen insensitivity syndrome: trinucleotide repeat polymorphisms, single-strand conformation polymorphism and direct detection of two novel mutations in the androgen receptor gene.
7649358 A single amino acid exchange abolishes dimerization of the androgen receptor and causes Reifenstein syndrome.
7671849 Androgen receptor defects: historical, clinical, and molecular perspectives.
7673412 Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias.
7712463 Prevalence of androgen receptor gene mutations in latent prostatic carcinomas from Japanese men.
7723794 Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer.
7909256 Molecular prenatal exclusion of familial partial androgen insensitivity (Reifenstein syndrome).
7910529 Molecular prenatal diagnosis of partial androgen insensitivity syndrome based on the Hind III polymorphism of the androgen receptor gene.
7929841 Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.
7937057 The androgen receptor gene mutations database.
7962294 An androgen receptor mutation causing androgen resistance in undervirilized male syndrome.
7970939 A practical approach to the detection of androgen receptor gene mutations and pedigree analysis in families with X-linked androgen insensitivity.
7981687 Detection of point mutations in the androgen receptor gene using non-isotopic single strand conformation polymorphism analysis.
7981689 Two mutations causing complete androgen insensitivity: a frame-shift in the steroid binding domain and a Cys-->Phe substitution in the second zinc finger of the androgen receptor.
7993455 Pregnancy after hormonal correction of severe spermatogenic defect due to mutation in androgen receptor gene.
8033918 Molecular characterization of the androgen receptor gene in boys with hypospadias.
8040309 Substitution of arginine-839 by cysteine or histidine in the androgen receptor causes different receptor phenotypes in cultured cells and coordinate degrees of clinical androgen resistance.
8096390 Complete androgen insensitivity syndrome associated with a de novo mutation of the androgen receptor gene detected by single strand conformation polymorphism.
8097257 Mutations of the androgen receptor gene identified in perineal hypospadias.
8103398 An exonic point mutation creates a MaeIII site in the androgen receptor gene of a family with complete androgen insensitivity syndrome.
8126121 Characterization of mutant androgen receptors causing partial androgen insensitivity syndrome.
8145761 Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
8162033 Complete androgen insensitivity due to mutations in the probable alpha-helical segments of the DNA-binding domain in the human androgen receptor.
8187068 Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers.
8205256 Single amino acid substitution (840Arg-->His) in the hormone-binding domain of the androgen receptor leads to incomplete androgen insensitivity syndrome associated with a thermolabile androgen receptor.
8213813 Sequence variation in the androgen receptor gene is not a common determinant of male sexual orientation.
8224266 A new mutation within the deoxyribonucleic acid-binding domain of the androgen receptor gene in a family with complete androgen insensitivity syndrome.
8240973 Mutations of androgen receptor gene in androgen insensitivity syndromes.
8274409 Androgen receptor gene mutations in human prostate cancer.
8281139 Androgen receptor gene mutation in male breast cancer.
8281140 A single-base substitution in exon 6 of the androgen receptor gene causing complete androgen insensitivity: the mutated receptor fails to transactivate but binds to DNA in vitro.
8292051 Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer.
8325932 A single amino acid substitution (Gly743 --> Val) in the steroid-binding domain of the human androgen receptor leads to Reifenstein syndrome.
8325950 Single strand conformation polymorphism analysis of androgen receptor gene mutations in patients with androgen insensitivity syndromes: application for diagnosis, genetic counseling, and therapy.
8339746 Molecular genetics of human androgen insensitivity.
8413310 A point mutation in the second zinc finger of the DNA-binding domain of the androgen receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance.
8446106 Substitution of valine-865 by methionine or leucine in the human androgen receptor causes complete or partial androgen insensitivity, respectively with distinct androgen receptor phenotypes.
8530589 Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol.
8550758 Partial androgen insensitivity caused by an androgen receptor mutation at amino acid 907 (Gly-->Arg) that results in decreased ligand binding affinity and reduced androgen receptor messenger ribonucleic acid levels.
8626869 A novel substitution (Leu707Arg) in exon 4 of the androgen receptor gene causes complete androgen resistance.
8628719 Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand conformation polymorphism analysis.
8647313 Molecular modeling and in vitro investigations of the human androgen receptor DNA-binding domain: application for the study of two mutations.
8683794 Androgen receptor gene mutations are rarely associated with isolated penile hypospadias.
8723113 The clinical and molecular spectrum of androgen insensitivity syndromes.
8768864 Different phenotypes in a family with androgen insensitivity caused by the same M780I point mutation in the androgen receptor gene.
8809734 Androgen insensitivity syndrome due to new mutations in the DNA-binding domain of the androgen receptor.
8823308 A novel missense mutation in the amino-terminal domain of the human androgen receptor gene in a family with partial androgen insensitivity syndrome causes reduced efficiency of protein translation.
8824883 Functional analysis of six androgen receptor mutations identified in patients with partial androgen insensitivity syndrome.
8827083 Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome.
8830623 A frame-shift mutation of the androgen receptor gene in a patient with receptor-negative complete testicular feminization: comparison with a single base substitution in a receptor-reduced incomplete form.
8918984 Molecular basis of androgen insensitivity.
8990010 Mutations of the androgen receptor gene in patients with complete androgen insensitivity.
9000575 Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.
9001799 Rapid detection of a mutation hot-spot in the human androgen receptor.
9007482 Functional assessment and clinical classification of androgen sensitivity in patients with mutations of the androgen receptor gene.
9016528 The androgen receptor gene mutations database.
9039340 Clinical and biochemical investigations and molecular analysis of subjects with mutations in the androgen receptor gene.
9096391 The CAG repeat within the androgen receptor gene and its relationship to prostate cancer.
9106550 Germ-line and somatic mosaicism in the androgen insensitivity syndrome: implications for genetic counseling.
9160185 Molecular analysis of androgen resistance syndromes in Egyptian patients.
9184448 Androgen receptor gene mutations in prostate cancer.
9196614 Correlation of clinical, endocrine and molecular abnormalities with in vivo responses to high-dose testosterone in patients with partial androgen insensitivity syndrome.
9252933 Complete androgen insensitivity syndrome. Molecular characterization in two Chinese women.
9255042 DNA analysis of the androgen receptor gene in two cases with complete androgen insensitivity syndrome.
9302173 Androgen receptor point mutations as the underlying molecular defect in 2 patients with androgen insensitivity syndrome.
9328206 Wide variation in androgen receptor dysfunction in complete androgen insensitivity syndrome.
9329414 Etiologic classification of severe hypospadias: implications for prognosis and management.
9438000 Genetic alterations of androgen receptor gene in Japanese human prostate cancer.
9543136 Response to androgen treatment in a patient with partial androgen insensitivity and a mutation in the deoxyribonucleic acid-binding domain of the androgen receptor.
9544375 Molecular analysis of the androgen receptor gene in 4 patients with complete androgen insensitivity.
9554754 A new missense substitution at a mutational hot spot of the androgen receptor in siblings with complete androgen insensitivity syndrome.
9554755 An androgen receptor gene mutation (A645D) in a boy with a normal phenotype.
9607727 Partial androgen insensitivity and correlations with the predicted three dimensional structure of the androgen receptor ligand-binding domain.
9610419 One additional mutation at exon A amplifies thermolability of androgen receptor in a case with complete androgen insensitivity syndrome.
9627582 Inherited and de novo androgen receptor gene mutations: investigation of single-case families.
9698822 Mutations of androgen receptor gene in Brazilian patients with male pseudohermaphroditism.
9768671 Trafficking of androgen receptor mutants fused to green fluorescent protein: a new investigation of partial androgen insensitivity syndrome.
9788719 Analysis of the transactivation domain of the androgen receptor in patients with male infertility.
9816170 Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
9851768 Azoospermia associated with a mutation in the ligand-binding domain of an androgen receptor displaying normal ligand binding, but defective trans-activation.
9856504 Functional characterisation of mutations in the ligand-binding domain of the androgen receptor gene in patients with androgen insensitivity syndrome.
10022458 Discordant measures of androgen-binding kinetics in two mutant androgen receptors causing mild or partial androgen insensitivity, respectively.
10075738 Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate.
10092153 Screening for mutations in candidate genes for hypospadias.
10221692 Androgen receptor gene mutations in 46,XY females with germ cell tumours.
10221770 An androgen receptor mutation in the direct vicinity of the proposed C-terminal alpha-helix of the ligand binding domain containing the AF-2 transcriptional activating function core is associated with complete androgen insensitivity.
10332029 PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival.
10363963 Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.
10383460 Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription.
10400640 The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.
10404311 A case of complete testicular feminization: laparoscopic orchiectomy and analysis of androgen receptor gene mutation.
10458483 Point mutations in the steroid-binding domain of the androgen receptor gene of five Japanese patients with androgen insensitivity syndrome.
10470409 A new point mutation of the androgen receptor gene in a patient with partial androgen resistance and severe oligozoospermia.
10502786 A novel point mutation (R840S) in the androgen receptor in a Brazilian family with partial androgen insensitivity syndrome.
10543676 Directed pharmacological therapy of ambiguous genitalia due to an androgen receptor gene mutation.
10569618 Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a.
10571951 Analysis of exon 1 mutations in the androgen receptor gene.
10590024 Clinical and molecular spectrum of somatic mosaicism in androgen insensitivity syndrome.
10598582 A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1.
10625666 PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.
10629558 Androgen receptor gene mutations in hormone-refractory prostate cancer.
10690872 Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome.
10706109 Androgen receptor mutations in prostate cancer.
10840043 Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.
10930412 Androgen receptor interacts with a novel MYST protein, HBO1.
11121022 Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).
11231320 Polymorphism of the androgen receptor gene is associated with male pattern baldness.
11587068 Eight novel mutations of the androgen receptor gene in patients with androgen insensitivity syndrome.
11744994 Characterization of a novel receptor mutation A->T at exon 4 in complete androgen insensitivity syndrome and a carrier sibling via bidirectional polymorphism sequence analysis.
11906285 Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer.
12039962 Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.
12361945 RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor.
12415108 Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
12612053 DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
12958311 The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway.
14573606 Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
14609956 hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci.
14664718 The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity.
14756668 Concordance of phenotypic expression and gender identity in a large kindred with a mutation in the androgen receptor.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15525515 Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance.
15563469 The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
15634333 Androgen receptor function is modulated by the tissue-specific AR45 variant.
15772651 The DNA sequence of the human X chromosome.
15851746 A family with early-onset and rapidly progressive X-linked spinal and bulbar muscular atrophy.
15902657 Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.
16027218 Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.
16051670 hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes.
16129672 Structural basis for accommodation of nonsteroidal ligands in the androgen receptor.
16595706 Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains.
16641486 Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
16951154 Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.
17045208 Regulation of androgen receptor activity by tyrosine phosphorylation.
17311914 Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.
17494760 Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.
17550981 The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer.
17587566 PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
17591767 Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.
17711855 Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.
17911242 A surface on the androgen receptor that allosterically regulates coactivator binding.
18007036 Interaction between the androgen receptor and a segment of its corepressor SHP.
18084323 ZIP kinase plays a crucial role in androgen receptor-mediated transcription.
18222118 RanBP10 acts as a novel coactivator for the androgen receptor.
18451096 Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.
18451177 TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
19244107 A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
19345326 Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
19909775 TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.
20501646 The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.
20623637 Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.
20980437 CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21512132 MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.
22031296 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
22170608 Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
22334387 The androgen receptor gene mutations database: 2012 update.
23887938 CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
27535533 Analysis of protein-coding genetic variation in 60,706 humans.
OMIM ID Disease Name
300068 Androgen insensitivity syndrome
312300 Androgen insensitivity, partial
313200 Spinal and bulbar muscular atrophy X-linked 1
Domain Name Domain ID Source
A39248 A39248 PIR
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Andrgn_rcpt IPR001103 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
WD40/YVTN_repeat-like_dom_sf IPR015943 InterPro
NHR_like_dom_sf IPR035500 InterPro
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
Androgen_recep PF02166 Pfam
STROIDFINGER PR00047 PRINTS
ANDROGENR PR00521 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM