Protein: P06241

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P06241 (Uniprot) FYN_HUMAN FYN Tyrosine-protein kinase Fyn human No
Uniprot: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 327 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0006725 cellular aromatic compound metabolic process 494 3.09e-47 2.24e-87
GO:0007165 signal transduction 187 GO:0034641 cellular nitrogen compound metabolic process 35, 327 4.22e-144 6.90e-18
GO:0007165 signal transduction 187 GO:0006725 cellular aromatic compound metabolic process 494 5.44e-126 5.27e-27
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35, 327 1.59e-39 2.52e-03
GO:0010646 regulation of cell communication 284 GO:0006725 cellular aromatic compound metabolic process 494 4.64e-30 1.07e-07
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
49 GO:0006464 cellular protein modification process
49 GO:0031324 negative regulation of cellular metabolic process
49 GO:0010629 negative regulation of gene expression
49 GO:0051172 negative regulation of nitrogen compound metabolic process
49 GO:0006357 regulation of transcription from RNA polymerase II promoter
49 GO:0007165 signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
177 GO:0044267 cellular protein metabolic process
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
259 GO:0007165 signal transduction
274 GO:0007165 signal transduction
284 GO:0009966 regulation of signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
494 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
732 GO:0006355 regulation of transcription, DNA-templated
747 GO:0010467 gene expression
747 GO:0090304 nucleic acid metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
20 GO:0005886 plasma membrane
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
49 GO:0043232 intracellular non-membrane-bounded organelle
49 GO:0005654 nucleoplasm
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
177 GO:0005634 nucleus
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
254 GO:0005829 cytosol
254 GO:0005634 nucleus
259 GO:0005886 plasma membrane
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
494 GO:0005634 nucleus
563 GO:0005634 nucleus
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
732 GO:0043232 intracellular non-membrane-bounded organelle
732 GO:0031981 nuclear lumen
747 GO:0070013 intracellular organelle lumen
747 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0001764 neuron migration IEA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002250 adaptive immune response IEA
GO:0006468 protein phosphorylation NAS
GO:0006816 calcium ion transport NAS
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
GO:0007411 axon guidance TAS
GO:0007417 central nervous system development IBA
GO:0007596 blood coagulation TAS
GO:0007612 learning TAS
GO:0007631 feeding behavior TAS
GO:0008360 regulation of cell shape IEA
GO:0010629 negative regulation of gene expression IEA
GO:0010976 positive regulation of neuron projection development IEA
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
GO:0016477 cell migration IBA
GO:0018108 peptidyl-tyrosine phosphorylation IMP
GO:0030154 cell differentiation IBA
GO:0030168 platelet activation TAS
GO:0030900 forebrain development IEA
GO:0031295 T cell costimulation TAS
GO:0031397 negative regulation of protein ubiquitination IEA
GO:0035556 intracellular signal transduction TAS
GO:0036120 cellular response to platelet-derived growth factor stimulus IEA
GO:0038083 peptidyl-tyrosine autophosphorylation IBA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:0042110 T cell activation IBA
GO:0042127 regulation of cell proliferation IBA
GO:0042177 negative regulation of protein catabolic process IEA
GO:0042493 response to drug IEA
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
GO:0042981 regulation of apoptotic process IBA
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
GO:0043524 negative regulation of neuron apoptotic process IEA
GO:0045087 innate immune response IBA
GO:0045471 response to ethanol IEA
GO:0046854 phosphatidylinositol phosphorylation IEA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048013 ephrin receptor signaling pathway TAS
GO:0048813 dendrite morphogenesis IEA
GO:0050690 regulation of defense response to virus by virus TAS
GO:0050798 activated T cell proliferation IEA
GO:0050852 T cell receptor signaling pathway IDA
GO:0050900 leukocyte migration TAS
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0065009 regulation of molecular function IEA
GO:0071375 cellular response to peptide hormone stimulus IEA
GO:0071560 cellular response to transforming growth factor beta stimulus IEA
GO:0090314 positive regulation of protein targeting to membrane IEA
GO:1900182 positive regulation of protein localization to nucleus IEA
GO:1901216 positive regulation of neuron death IEA
GO:1902951 negative regulation of dendritic spine maintenance IEA
GO:1904645 response to amyloid-beta IEA
GO:1905664 regulation of calcium ion import across plasma membrane IEA
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005739 mitochondrion IEA
GO:0005768 endosome IDA
GO:0005829 cytosol TAS
GO:0005884 actin filament IEA
GO:0005886 plasma membrane IDA
GO:0014069 postsynaptic density ISS
GO:0030425 dendrite ISS
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
GO:0045121 membrane raft IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
Interactor Also a MoonDB EMF protein
MEOX2_HUMAN Yes: P50222 (MoonDB)
ATX1_HUMAN Yes: P54253 (MoonDB)
HS90B_HUMAN Yes: P08238 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
MOS_HUMAN No
3BP2_HUMAN No
RHG33_HUMAN No
ADA15_HUMAN No
F90A1_HUMAN No
F110A_HUMAN No
TNFL6_HUMAN No
HXC8_HUMAN No
TRI39_HUMAN No
BAG4_HUMAN No
SUV91_HUMAN No
KDM1A_HUMAN Yes: O60341 (MoonDB)
SUV92_HUMAN No
ORC1_HUMAN No
CDC37_HUMAN Yes: Q16543 (MoonDB)
RHG32_HUMAN No
5HT6R_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
ABL2_HUMAN Yes: P42684 (MoonDB)
AIRE_HUMAN No
AKAP6_HUMAN No
ANM6_HUMAN No
APOL5_HUMAN No
ARHGB_HUMAN No
ASAP1_HUMAN No
ASAP2_HUMAN No
ASB16_HUMAN No
BAZ2A_HUMAN No
BCAR1_HUMAN No
BMP8B_HUMAN No
BRCA2_HUMAN No
BRPF3_HUMAN No
CAC1F_HUMAN No
CAF1A_HUMAN No
CAPON_HUMAN No
CBLB_HUMAN No
CBL_HUMAN No
CCR10_HUMAN No
CD2AP_HUMAN No
CDC27_HUMAN No
CDKL5_HUMAN No
CELR3_HUMAN No
CENPA_HUMAN No
CG025_HUMAN No
CH033_HUMAN No
CKAP5_HUMAN No
CNTFR_HUMAN No
CNTP1_HUMAN No
CO6_HUMAN No
CP4F2_HUMAN No
CSMD2_HUMAN No
CTLA4_HUMAN No
CTNB1_HUMAN No
DAB2_HUMAN No
DAG1_HUMAN No
DCE1_HUMAN No
DDX41_HUMAN No
DKKL1_HUMAN No
DLGP1_HUMAN No
DLGP2_HUMAN No
DLGP3_HUMAN No
DLGP4_HUMAN No
DLX4_HUMAN No
DNSL2_HUMAN No
DOCK1_HUMAN No
DOCK3_HUMAN No
DPOD1_HUMAN No
DTX3_HUMAN No
DUS15_HUMAN No
DYN3_HUMAN No
E41L3_HUMAN No
EFS_HUMAN No
EPS15_HUMAN Yes: P42566 (MoonDB)
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERRFI_HUMAN No
EXTL3_HUMAN No
FAK1_HUMAN No
FANCA_HUMAN Yes: O15360 (MoonDB)
FCG2B_HUMAN No
FCG2C_HUMAN No
FINC_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
FLNC_HUMAN No
FOXF2_HUMAN No
FYB1_HUMAN No
GABR1_HUMAN No
GASR_HUMAN No
GCFC2_HUMAN No
GNS_HUMAN No
GPR45_HUMAN No
GPR63_HUMAN No
GUC2D_HUMAN No
HCN2_HUMAN No
HCN4_HUMAN No
HDAC6_HUMAN No
HEXA_HUMAN No
HNRPR_HUMAN No
I20L2_HUMAN No
ICAL_HUMAN No
IL3RA_HUMAN No
KHDR1_HUMAN No
KI67_HUMAN No
KMT2B_HUMAN No
KPCD_HUMAN No
KPCT_HUMAN No
LAP2B_HUMAN No
LAT_HUMAN No
LRBA_HUMAN No
LTBP2_HUMAN No
M4K1_HUMAN No
M4K5_HUMAN No
MAAI_HUMAN No
MED14_HUMAN No
MED28_HUMAN No
MEPE_HUMAN No
MYPT1_HUMAN No
NBEA_HUMAN No
NCKP5_HUMAN No
NCKX1_HUMAN No
NEK8_HUMAN No
NELFB_HUMAN No
NFASC_HUMAN No
NFS1_HUMAN No
NKX21_HUMAN No
NPVF_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
PAK2_HUMAN No
PAR3_HUMAN No
PAX3_HUMAN No
PAX7_HUMAN No
PDC6I_HUMAN Yes: Q8WUM4 (MoonDB)
PDE4D_HUMAN No
PDIA2_HUMAN No
PHAG1_HUMAN No
PKD1_HUMAN No
PPR3D_HUMAN No
PRAX_HUMAN No
PRIC3_HUMAN No
PTN4_HUMAN No
RIMS1_HUMAN No
RIMS2_HUMAN No
RIN3_HUMAN Yes: Q8TB24 (MoonDB)
RP1L1_HUMAN No
RPGF1_HUMAN No
RPP38_HUMAN No
RRAS_HUMAN No
RTN4_HUMAN No
SELN_HUMAN No
SEM7A_HUMAN No
SF3B4_HUMAN No
SH21A_HUMAN No
SHAN3_HUMAN No
SHRM2_HUMAN No
SNX12_HUMAN No
SNX17_HUMAN No
SNX3_HUMAN No
SNX8_HUMAN No
SOS1_HUMAN No
SOS2_HUMAN No
SP1_HUMAN No
SPN90_HUMAN No
SREC2_HUMAN No
STF1_HUMAN No
SYNJ2_HUMAN No
TAU_HUMAN No
TDRD1_HUMAN No
TELT_HUMAN No
TF3A_HUMAN No
TGON2_HUMAN No
TNNT1_HUMAN No
TRAIP_HUMAN No
TSKS_HUMAN No
TULP1_HUMAN No
TULP4_HUMAN No
UHRF2_HUMAN No
VAV2_HUMAN Yes: P52735 (MoonDB)
VAV_HUMAN No
VP13A_HUMAN No
WBP11_HUMAN No
WIPF1_HUMAN No
WNK2_HUMAN No
XRCC1_HUMAN No
PMID Article Title
1533589 Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.
1699196 In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts.
3099169 Isolation and oncogenic potential of a novel human src-like gene.
3526330 Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.
7568038 p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
7664083 High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
7687536 Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.
7822789 Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.
8206991 Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization.
8394019 Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.
8681387 Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
8805554 Solution structure and peptide binding of the SH3 domain from human Fyn.
8961927 Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
9038210 Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
9207119 Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.
9351806 The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
9741627 A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.
10196263 Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.
10498895 Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.
10790433 Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
11005864 T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.
11162638 Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.
11518702 The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
11536198 Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.
12218089 Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
12545174 SAP couples Fyn to SLAM immune receptors.
12788081 p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.
14574404 The DNA sequence and analysis of human chromosome 6.
14707117 Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
14757743 Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
14761972 Regulation of TRPC6 channel activity by tyrosine phosphorylation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15489916 Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
15536091 Fyn phosphorylates human MAP-2c on tyrosine 67.
15537652 Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.
15557120 Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance.
16387660 Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.
16841086 Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.
17194753 Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.
17344846 Patterns of somatic mutation in human cancer genomes.
17925405 Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.
18056706 Regulation of FynT function by dual domain docking on PAG/Cbp.
18088087 Phosphoproteome of resting human platelets.
18258597 Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19054851 Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
19179337 Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1.
19369195 Large-scale proteomics analysis of the human kinome.
19652227 Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.
19807924 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
22080863 T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
27335501 ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.
No results found.
Domain Name Domain ID Source
TVHUSY A24314 PIR
Prot_kinase_dom IPR000719 InterPro
SH2 IPR000980 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
SH3_domain IPR001452 InterPro
Tyr_kinase_AS IPR008266 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Tyr_kinase_cat_dom IPR020635 InterPro
Fyn/Yrk_SH3 IPR035750 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
Pkinase_Tyr PF07714 Pfam
TYRKINASE PR00109 PRINTS
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_TYR PS00109 PROSITE
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
TyrKc SM00219 SMART
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SSF56112 SSF56112 SUPFAM
SH3_Fyn_Yrk cd12006 CDD