Protein: P04792

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P04792 (Uniprot) HSPB1_HUMAN HSPB1 Heat shock protein beta-1 human No
Uniprot: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1 GO:0034641 cellular nitrogen compound metabolic process 245 4.22e-144 6.90e-18
GO:0007165 signal transduction 1 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294, 467 4.83e-02 1.79e-71
GO:0007165 signal transduction 1 GO:0006725 cellular aromatic compound metabolic process 395 5.44e-126 5.27e-27
GO:0019538 protein metabolic process 164, 292, 376, 379, 393, 404 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294, 467 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
6 GO:0034645 cellular macromolecule biosynthetic process
6 GO:0010467 gene expression
6 GO:0090304 nucleic acid metabolic process
6 GO:0060255 regulation of macromolecule metabolic process
21 GO:0060255 regulation of macromolecule metabolic process
88 GO:0007165 signal transduction
164 GO:0044267 cellular protein metabolic process
164 GO:0060255 regulation of macromolecule metabolic process
164 GO:0007165 signal transduction
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
203 GO:0016070 RNA metabolic process
203 GO:0010468 regulation of gene expression
211 GO:0034645 cellular macromolecule biosynthetic process
211 GO:0044271 cellular nitrogen compound biosynthetic process
211 GO:0090304 nucleic acid metabolic process
211 GO:0060255 regulation of macromolecule metabolic process
242 GO:0022607 cellular component assembly
242 GO:0010605 negative regulation of macromolecule metabolic process
242 GO:0045934 negative regulation of nucleobase-containing compound metabolic process
242 GO:0009893 positive regulation of metabolic process
242 GO:2000112 regulation of cellular macromolecule biosynthetic process
242 GO:0010468 regulation of gene expression
242 GO:1903506 regulation of nucleic acid-templated transcription
242 GO:0007165 signal transduction
243 GO:0034645 cellular macromolecule biosynthetic process
243 GO:0044271 cellular nitrogen compound biosynthetic process
243 GO:0006464 cellular protein modification process
243 GO:0031325 positive regulation of cellular metabolic process
243 GO:0010604 positive regulation of macromolecule metabolic process
243 GO:0051173 positive regulation of nitrogen compound metabolic process
243 GO:0051252 regulation of RNA metabolic process
243 GO:0031326 regulation of cellular biosynthetic process
243 GO:0032268 regulation of cellular protein metabolic process
243 GO:0010468 regulation of gene expression
243 GO:0010556 regulation of macromolecule biosynthetic process
243 GO:0007165 signal transduction
245 GO:0044271 cellular nitrogen compound biosynthetic process
245 GO:0090304 nucleic acid metabolic process
245 GO:1901362 organic cyclic compound biosynthetic process
245 GO:2000112 regulation of cellular macromolecule biosynthetic process
245 GO:0019219 regulation of nucleobase-containing compound metabolic process
249 GO:0060255 regulation of macromolecule metabolic process
292 GO:0044267 cellular protein metabolic process
292 GO:0010467 gene expression
294 GO:0000398 mRNA splicing, via spliceosome
295 GO:0060255 regulation of macromolecule metabolic process
305 GO:0060255 regulation of macromolecule metabolic process
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
379 GO:0044267 cellular protein metabolic process
379 GO:0009059 macromolecule biosynthetic process
379 GO:0051246 regulation of protein metabolic process
393 GO:0044267 cellular protein metabolic process
395 GO:0006139 nucleobase-containing compound metabolic process
395 GO:0019538 protein metabolic process
404 GO:0044267 cellular protein metabolic process
404 GO:0007165 signal transduction
410 GO:0010467 gene expression
410 GO:0007165 signal transduction
423 GO:0006464 cellular protein modification process
423 GO:0090304 nucleic acid metabolic process
423 GO:0060255 regulation of macromolecule metabolic process
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
485 GO:0034645 cellular macromolecule biosynthetic process
485 GO:0090304 nucleic acid metabolic process
512 GO:0035556 intracellular signal transduction
512 GO:0006468 protein phosphorylation
512 GO:0060255 regulation of macromolecule metabolic process
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
557 GO:0034645 cellular macromolecule biosynthetic process
557 GO:0044265 cellular macromolecule catabolic process
557 GO:0044271 cellular nitrogen compound biosynthetic process
557 GO:0035556 intracellular signal transduction
557 GO:0016071 mRNA metabolic process
557 GO:0010629 negative regulation of gene expression
557 GO:0031325 positive regulation of cellular metabolic process
557 GO:0051247 positive regulation of protein metabolic process
557 GO:0051252 regulation of RNA metabolic process
557 GO:0009894 regulation of catabolic process
557 GO:0031326 regulation of cellular biosynthetic process
557 GO:0010556 regulation of macromolecule biosynthetic process
557 GO:0031399 regulation of protein modification process
577 GO:0006464 cellular protein modification process
577 GO:0033554 cellular response to stress
577 GO:0006796 phosphate-containing compound metabolic process
577 GO:0031326 regulation of cellular biosynthetic process
577 GO:0010556 regulation of macromolecule biosynthetic process
577 GO:0009966 regulation of signal transduction
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
663 GO:0015833 peptide transport
663 GO:0008104 protein localization
692 GO:0016070 RNA metabolic process
692 GO:0044271 cellular nitrogen compound biosynthetic process
692 GO:0010467 gene expression
692 GO:0019538 protein metabolic process
692 GO:2000112 regulation of cellular macromolecule biosynthetic process
841 GO:0044267 cellular protein metabolic process
841 GO:0009059 macromolecule biosynthetic process
841 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
6 GO:0043232 intracellular non-membrane-bounded organelle
6 GO:0005654 nucleoplasm
11 GO:0005634 nucleus
39 GO:0043232 intracellular non-membrane-bounded organelle
43 GO:0005634 nucleus
88 GO:0012505 endomembrane system
88 GO:0031982 vesicle
167 GO:0005654 nucleoplasm
174 GO:0016021 integral component of membrane
203 GO:0070013 intracellular organelle lumen
203 GO:0005634 nucleus
206 GO:0005829 cytosol
211 GO:0005829 cytosol
211 GO:0031981 nuclear lumen
242 GO:0043232 intracellular non-membrane-bounded organelle
242 GO:0070013 intracellular organelle lumen
242 GO:0005634 nucleus
243 GO:0005829 cytosol
243 GO:0070013 intracellular organelle lumen
243 GO:0044428 nuclear part
245 GO:0005634 nucleus
249 GO:0005829 cytosol
249 GO:0005634 nucleus
249 GO:0031982 vesicle
291 GO:0043232 intracellular non-membrane-bounded organelle
291 GO:0005634 nucleus
292 GO:0043232 intracellular non-membrane-bounded organelle
292 GO:0031981 nuclear lumen
293 GO:0005634 nucleus
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
295 GO:0043232 intracellular non-membrane-bounded organelle
295 GO:0005634 nucleus
305 GO:0005634 nucleus
317 GO:0005829 cytosol
376 GO:0005829 cytosol
376 GO:0005634 nucleus
379 GO:0005829 cytosol
379 GO:0005576 extracellular region
379 GO:0005634 nucleus
393 GO:0043232 intracellular non-membrane-bounded organelle
393 GO:0005634 nucleus
395 GO:0005634 nucleus
404 GO:0005829 cytosol
404 GO:0012505 endomembrane system
404 GO:0031982 vesicle
410 GO:0005634 nucleus
423 GO:0005829 cytosol
423 GO:0005634 nucleus
467 GO:0005654 nucleoplasm
485 GO:0043232 intracellular non-membrane-bounded organelle
485 GO:0005634 nucleus
512 GO:0005829 cytosol
544 GO:0005829 cytosol
544 GO:0005634 nucleus
557 GO:0005829 cytosol
557 GO:0044421 extracellular region part
557 GO:0005654 nucleoplasm
557 GO:0031982 vesicle
577 GO:0005829 cytosol
577 GO:0043232 intracellular non-membrane-bounded organelle
577 GO:0070013 intracellular organelle lumen
577 GO:0044428 nuclear part
577 GO:0031982 vesicle
651 GO:0005829 cytosol
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
663 GO:0005829 cytosol
663 GO:0031982 vesicle
692 GO:0031981 nuclear lumen
841 GO:0005829 cytosol
841 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001895 retina homeostasis IEP
GO:0001932 regulation of protein phosphorylation IMP
GO:0006446 regulation of translational initiation TAS
GO:0006469 negative regulation of protein kinase activity ISS
GO:0006928 movement of cell or subcellular component TAS
GO:0006986 response to unfolded protein NAS
GO:0009615 response to virus IEP
GO:0010506 regulation of autophagy NAS
GO:0032731 positive regulation of interleukin-1 beta production ISS
GO:0035556 intracellular signal transduction IMP
GO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IMP
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process ISS
GO:0043066 negative regulation of apoptotic process TAS
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling ISS
GO:0043488 regulation of mRNA stability TAS
GO:0043536 positive regulation of blood vessel endothelial cell migration IMP
GO:0045766 positive regulation of angiogenesis IMP
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0061077 chaperone-mediated protein folding IMP
GO:0070527 platelet aggregation IMP
GO:0071901 negative regulation of protein serine/threonine kinase activity IEA
GO:0099641 anterograde axonal protein transport IMP
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISS
GO:2001028 positive regulation of endothelial cell chemotaxis IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000502 proteasome complex ISS
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005819 spindle IEA
GO:0005829 cytosol TAS
GO:0005856 cytoskeleton TAS
GO:0005886 plasma membrane IEA
GO:0005925 focal adhesion IDA
GO:0030018 Z disc IEA
GO:0031012 extracellular matrix IDA
GO:0070062 extracellular exosome IDA
GO:1904115 axon cytoplasm IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0031012 extracellular matrix 1.58e-13 4.18e-03
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005819 spindle GO:0005886 plasma membrane 2.71e-05 1.10e-14
GO:0005829 cytosol GO:0031012 extracellular matrix 4.46e-06 5.18e-08
Interactor Also a MoonDB EMF protein
CCDB1_HUMAN No
PSA3_HUMAN Yes: P25788 (MoonDB)
HNRPF_HUMAN No
TRI54_HUMAN No
RBM39_HUMAN No
BAG3_HUMAN No
PSB1_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
OPTN_HUMAN No
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
CCNC_HUMAN No
PSB2_HUMAN No
CCHCR_HUMAN No
KANL1_HUMAN No
NBAS_HUMAN No
1433B_HUMAN No
1433E_HUMAN Yes: P62258 (MoonDB)
1433F_HUMAN No
1433T_HUMAN No
1433Z_HUMAN Yes: P63104 (MoonDB)
A0A0B4J220_HUMAN No
ACAP2_HUMAN No
ACBD6_HUMAN No
ACTN1_HUMAN No
ACTN2_HUMAN No
ACTN4_HUMAN No
ADCY9_HUMAN No
ADDG_HUMAN No
AGAP3_HUMAN No
AGAP4_HUMAN No
AGAP5_HUMAN No
AGAP7_HUMAN No
AGAP9_HUMAN No
AKT1_HUMAN No
ANK1_HUMAN No
ANKR7_HUMAN No
ANXA1_HUMAN No
AP2B1_HUMAN No
APC7_HUMAN No
ARBK2_HUMAN No
ARHG7_HUMAN No
ARHL2_HUMAN No
ARI1_HUMAN No
ARMT1_HUMAN No
ARRD5_HUMAN No
ATX10_HUMAN No
B4DXL2_HUMAN No
BAT1_HUMAN No
BICL1_HUMAN No
CALR_HUMAN No
CB073_HUMAN No
CBX1_HUMAN No
CCD32_HUMAN No
CCD70_HUMAN No
CCNO_HUMAN No
CD123_HUMAN No
CENPK_HUMAN No
CEP78_HUMAN No
CETN3_HUMAN No
CF251_HUMAN No
CK5P3_HUMAN No
CLCN3_HUMAN No
CPSF3_HUMAN No
CRBB2_HUMAN No
CRGC_HUMAN No
CRNL1_HUMAN No
CRYAA_HUMAN Yes: P02489 (MoonDB)
CRYAB_HUMAN Yes: P02511 (MoonDB)
CT55_HUMAN No
DAXX_HUMAN No
DCAM_HUMAN No
DESM_HUMAN No
DFFA_HUMAN No
DJC21_HUMAN No
DMAP1_HUMAN No
DNLI1_HUMAN No
DP13A_HUMAN Yes: Q9UKG1 (MoonDB)
E41L1_HUMAN No
E41L2_HUMAN No
E41L3_HUMAN No
ECM29_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
EHD1_HUMAN No
EIF3M_HUMAN No
ENPP2_HUMAN No
ERCC5_HUMAN No
ERIP6_HUMAN No
F13A_HUMAN No
FA71D_HUMAN No
FKBP4_HUMAN No
FLNB_HUMAN No
FRIH_HUMAN No
FXR1_HUMAN No
GAPD1_HUMAN No
GARS_HUMAN No
GATA1_HUMAN No
GDIB_HUMAN No
GET4_HUMAN Yes: Q7L5D6 (MoonDB)
GLMN_HUMAN No
GNPAT_HUMAN No
GOG8A_HUMAN No
GRAP1_HUMAN No
GRP78_HUMAN No
GSTO1_HUMAN No
GTSF1_HUMAN No
GUC1A_HUMAN No
HAUS8_HUMAN No
HECD1_HUMAN No
HINFP_HUMAN No
HNRH2_HUMAN No
HNRPD_HUMAN Yes: Q14103 (MoonDB)
HNRPU_HUMAN No
HS90A_HUMAN Yes: P07900 (MoonDB)
HSP74_HUMAN No
HSPB8_HUMAN No
HUWE1_HUMAN No
I20L2_HUMAN No
IF1AX_HUMAN No
IF2A_HUMAN No
IF2M_HUMAN No
IF4A2_HUMAN No
IF4G1_HUMAN No
IF4G2_HUMAN No
IF4G3_HUMAN No
IF5_HUMAN No
IGBP1_HUMAN No
IGS21_HUMAN No
IMA4_HUMAN No
INP5K_HUMAN No
IPYR_HUMAN No
K1C18_HUMAN No
K2C72_HUMAN No
KCC1A_HUMAN No
KCMF1_HUMAN No
KCTD3_HUMAN No
KLC1_HUMAN No
LBHD1_HUMAN No
LBP_HUMAN No
LONF1_HUMAN No
LRIF1_HUMAN No
LSM3_HUMAN Yes: P62310 (MoonDB)
LUZP1_HUMAN No
MAPK2_HUMAN No
MAPK3_HUMAN No
MCM6_HUMAN No
MED31_HUMAN No
MFAP1_HUMAN No
ML12A_HUMAN No
ML12B_HUMAN No
MPH6_HUMAN No
MRGBP_HUMAN No
MSL1_HUMAN No
MTMR5_HUMAN No
MYG1_HUMAN No
MYL9_HUMAN No
MYLK_HUMAN No
NEK10_HUMAN No
NEXN_HUMAN No
NFU1_HUMAN No
NP1L1_HUMAN No
NSE4A_HUMAN No
NVL_HUMAN No
OBSL1_HUMAN No
OSBL9_HUMAN No
P2R3C_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PAF1_HUMAN No
PALM3_HUMAN No
PASK_HUMAN Yes: Q96RG2 (MoonDB)
PELO_HUMAN No
PGM2_HUMAN No
PHIPL_HUMAN No
PLMN_HUMAN No
PNISR_HUMAN No
PNPT1_HUMAN No
POPD1_HUMAN No
PPBI_HUMAN No
PPM1A_HUMAN No
PR40A_HUMAN Yes: O75400 (MoonDB)
PRP19_HUMAN Yes: Q9UMS4 (MoonDB)
PRS4_HUMAN No
PSA6_HUMAN No
PSMD1_HUMAN No
PTN3_HUMAN No
PTPRA_HUMAN No
QCR7_HUMAN No
RAB41_HUMAN No
RAB43_HUMAN No
RALA_HUMAN No
RASF9_HUMAN No
RBM25_HUMAN No
RBM48_HUMAN No
RBX1_HUMAN No
RD23A_HUMAN No
RHG28_HUMAN No
RIF1_HUMAN No
RM28_HUMAN No
RM40_HUMAN No
ROA2_HUMAN No
RPAP3_HUMAN No
RSPH3_HUMAN No
RSSA_HUMAN No
RT23_HUMAN No
RUXF_HUMAN No
RYBP_HUMAN No
S10A4_HUMAN No
SAT1_HUMAN No
SEC13_HUMAN No
SF3A3_HUMAN No
SF3B3_HUMAN No
SIM2_HUMAN No
SKAP_HUMAN No
SMCA2_HUMAN No
SMCA4_HUMAN No
SMRD1_HUMAN No
SNAA_HUMAN No
SNW1_HUMAN No
SPAC7_HUMAN No
SPAT7_HUMAN No
SPIN1_HUMAN No
SPN90_HUMAN No
SPT5H_HUMAN No
SPTB2_HUMAN No
SQSTM_HUMAN Yes: Q13501 (MoonDB)
SRP72_HUMAN No
SRTD1_HUMAN No
SUH_HUMAN No
SYCE1_HUMAN No
SYIM_HUMAN No
SYTC_HUMAN No
TBC3B_HUMAN No
TBCD1_HUMAN No
TCTP_HUMAN No
TEBP_HUMAN No
TGFI1_HUMAN No
THOC5_HUMAN No
TIF1A_HUMAN No
TMCO3_HUMAN No
TOM70_HUMAN No
TOX4_HUMAN No
TRBP2_HUMAN No
TT39C_HUMAN No
TTC3_HUMAN No
TXIP1_HUMAN No
TXNL1_HUMAN No
U520_HUMAN No
U5S1_HUMAN No
UFD1_HUMAN Yes: Q92890 (MoonDB)
UQCC2_HUMAN No
VIGLN_HUMAN No
VIME_HUMAN Yes: P08670 (MoonDB)
WASC3_HUMAN No
WDR83_HUMAN No
WWP1_HUMAN Yes: Q9H0M0 (MoonDB)
XPO1_HUMAN No
XRCC5_HUMAN Yes: P13010 (MoonDB)
ZBT17_HUMAN No
ZBT37_HUMAN No
ZFAT_HUMAN No
ZN131_HUMAN No
ZN197_HUMAN No
ZNRF3_HUMAN No
ZO2_HUMAN No
PMID Article Title
1332886 Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
1560006 Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.
1730670 Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.
1763035 The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.
2243808 cDNA sequence of a human heat shock protein HSP27.
2295696 Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins.
2743305 Induction of the estrogen-regulated '24K' protein by heat shock.
3714473 Sequence and organization of genes encoding the human 27 kDa heat shock protein.
8093612 Small heat shock proteins are molecular chaperones.
8325890 The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein.
8774846 A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
9110174 Large-scale concatenation cDNA sequencing.
10383393 Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.
10751411 Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.
10777697 Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells.
11342557 HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27).
12853948 The DNA sequence of human chromosome 7.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15122254 Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15976317 Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.
16548883 Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17924679 Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
18088087 Phosphoproteome of resting human platelets.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18832141 Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.
18952241 A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation.
19166925 PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.
19369195 Large-scale proteomics analysis of the human kinome.
19464326 HSPB7 is a SC35 speckle resident small heat shock protein.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20178975 Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.
20870250 A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22176143 HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients.
22206013 The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23643870 Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.
23728742 Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments.
23948568 Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
25965061 Characterization of mutants of human small heat shock protein HspB1 carrying replacements in the n-terminal domain and associated with hereditary motor neuron diseases.
27492805 Molecular chaperones in the pathogenesis of amyotrophic lateral sclerosis: the role of HSPB1.
28144995 Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
OMIM ID Disease Name
606595 Charcot-Marie-Tooth disease 2F
608634 Neuronopathy, distal hereditary motor, 2B
Domain Name Domain ID Source
Alpha-crystallin/HSP IPR001436 InterPro
A-crystallin/Hsp20_dom IPR002068 InterPro
HSP20-like_chaperone IPR008978 InterPro
HSP20 IPR031107 InterPro
HSP20 PF00011 Pfam
ACRYSTALLIN PR00299 PRINTS
SHSP PS01031 PROSITE
PTHR11527 PTHR11527 PANTHER
HHHU27 S12102 PIR
SSF49764 SSF49764 SUPFAM