Protein: P04637

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P04637 (Uniprot) P53_HUMAN TP53 Cellular tumor antigen p53 human No
Uniprot: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 4 GO:0006139 nucleobase-containing compound metabolic process 463 1.10e-111 5.07e-25
Module ID (MoonGO) GO ID (BP) GO Name
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
4 GO:0035556 intracellular signal transduction
4 GO:0031399 regulation of protein modification process
4 GO:0009966 regulation of signal transduction
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
25 GO:0006464 cellular protein modification process
25 GO:0010467 gene expression
25 GO:0060255 regulation of macromolecule metabolic process
25 GO:0007165 signal transduction
28 GO:0006464 cellular protein modification process
28 GO:0031324 negative regulation of cellular metabolic process
28 GO:0010605 negative regulation of macromolecule metabolic process
28 GO:0051172 negative regulation of nitrogen compound metabolic process
28 GO:0031325 positive regulation of cellular metabolic process
28 GO:0010604 positive regulation of macromolecule metabolic process
28 GO:0051173 positive regulation of nitrogen compound metabolic process
28 GO:0048584 positive regulation of response to stimulus
28 GO:0009966 regulation of signal transduction
28 GO:0006355 regulation of transcription, DNA-templated
51 GO:0060255 regulation of macromolecule metabolic process
94 GO:0006464 cellular protein modification process
94 GO:0060255 regulation of macromolecule metabolic process
120 GO:0006464 cellular protein modification process
120 GO:0070887 cellular response to chemical stimulus
120 GO:0031324 negative regulation of cellular metabolic process
120 GO:0010605 negative regulation of macromolecule metabolic process
120 GO:0051172 negative regulation of nitrogen compound metabolic process
120 GO:0031325 positive regulation of cellular metabolic process
120 GO:0010604 positive regulation of macromolecule metabolic process
120 GO:0051173 positive regulation of nitrogen compound metabolic process
120 GO:0006355 regulation of transcription, DNA-templated
120 GO:0007165 signal transduction
123 GO:0006464 cellular protein modification process
123 GO:0006355 regulation of transcription, DNA-templated
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
196 GO:0034645 cellular macromolecule biosynthetic process
196 GO:0006464 cellular protein modification process
196 GO:0090304 nucleic acid metabolic process
196 GO:0031326 regulation of cellular biosynthetic process
196 GO:0010468 regulation of gene expression
196 GO:0010556 regulation of macromolecule biosynthetic process
196 GO:0007165 signal transduction
201 GO:0006464 cellular protein modification process
201 GO:0031325 positive regulation of cellular metabolic process
201 GO:0010604 positive regulation of macromolecule metabolic process
201 GO:0051173 positive regulation of nitrogen compound metabolic process
201 GO:0010646 regulation of cell communication
201 GO:0023051 regulation of signaling
201 GO:0006355 regulation of transcription, DNA-templated
201 GO:0007165 signal transduction
207 GO:0007165 signal transduction
287 GO:0006464 cellular protein modification process
287 GO:0006355 regulation of transcription, DNA-templated
305 GO:0060255 regulation of macromolecule metabolic process
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
377 GO:0007165 signal transduction
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
420 GO:0006464 cellular protein modification process
463 GO:0090304 nucleic acid metabolic process
463 GO:0060255 regulation of macromolecule metabolic process
465 GO:0031325 positive regulation of cellular metabolic process
465 GO:0010604 positive regulation of macromolecule metabolic process
465 GO:0051173 positive regulation of nitrogen compound metabolic process
465 GO:0006357 regulation of transcription from RNA polymerase II promoter
465 GO:0007165 signal transduction
469 GO:0060255 regulation of macromolecule metabolic process
475 GO:0031325 positive regulation of cellular metabolic process
475 GO:0060255 regulation of macromolecule metabolic process
526 GO:0016070 RNA metabolic process
526 GO:0034645 cellular macromolecule biosynthetic process
526 GO:0033554 cellular response to stress
526 GO:0034654 nucleobase-containing compound biosynthetic process
526 GO:0031325 positive regulation of cellular metabolic process
526 GO:0010604 positive regulation of macromolecule metabolic process
526 GO:0051173 positive regulation of nitrogen compound metabolic process
526 GO:0006468 protein phosphorylation
526 GO:0010468 regulation of gene expression
526 GO:0031399 regulation of protein modification process
526 GO:0009966 regulation of signal transduction
534 GO:0007166 cell surface receptor signaling pathway
534 GO:0006464 cellular protein modification process
534 GO:0033554 cellular response to stress
534 GO:0010467 gene expression
534 GO:0006796 phosphate-containing compound metabolic process
534 GO:0060255 regulation of macromolecule metabolic process
534 GO:0009966 regulation of signal transduction
534 GO:0009628 response to abiotic stimulus
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
728 GO:0044267 cellular protein metabolic process
728 GO:0031325 positive regulation of cellular metabolic process
728 GO:0010604 positive regulation of macromolecule metabolic process
728 GO:0051173 positive regulation of nitrogen compound metabolic process
728 GO:0051252 regulation of RNA metabolic process
728 GO:0010468 regulation of gene expression
728 GO:0007165 signal transduction
758 GO:0016070 RNA metabolic process
758 GO:0034645 cellular macromolecule biosynthetic process
758 GO:0044271 cellular nitrogen compound biosynthetic process
758 GO:0044267 cellular protein metabolic process
758 GO:0009893 positive regulation of metabolic process
758 GO:0010468 regulation of gene expression
758 GO:0019219 regulation of nucleobase-containing compound metabolic process
780 GO:0006355 regulation of transcription, DNA-templated
823 GO:0044267 cellular protein metabolic process
823 GO:0071310 cellular response to organic substance
823 GO:0010629 negative regulation of gene expression
823 GO:0031325 positive regulation of cellular metabolic process
823 GO:0010628 positive regulation of gene expression
823 GO:0051173 positive regulation of nitrogen compound metabolic process
823 GO:0006357 regulation of transcription from RNA polymerase II promoter
823 GO:0007165 signal transduction
837 GO:0009887 animal organ morphogenesis
837 GO:0006915 apoptotic process
837 GO:0007166 cell surface receptor signaling pathway
837 GO:0033554 cellular response to stress
837 GO:0018193 peptidyl-amino acid modification
837 GO:0051130 positive regulation of cellular component organization
837 GO:1902533 positive regulation of intracellular signal transduction
837 GO:0001934 positive regulation of protein phosphorylation
837 GO:0045893 positive regulation of transcription, DNA-templated
837 GO:0006357 regulation of transcription from RNA polymerase II promoter
837 GO:0051338 regulation of transferase activity
837 GO:0009628 response to abiotic stimulus
837 GO:0001501 skeletal system development
Module ID (MoonGO) GO ID (CC) GO Name
2 GO:0005829 cytosol
2 GO:0005634 nucleus
4 GO:0005829 cytosol
4 GO:0005634 nucleus
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
25 GO:0005829 cytosol
25 GO:0005634 nucleus
28 GO:0005829 cytosol
28 GO:0043232 intracellular non-membrane-bounded organelle
28 GO:0005654 nucleoplasm
51 GO:0005634 nucleus
120 GO:0005829 cytosol
120 GO:0043232 intracellular non-membrane-bounded organelle
120 GO:0005654 nucleoplasm
123 GO:0043232 intracellular non-membrane-bounded organelle
123 GO:0005654 nucleoplasm
155 GO:0005634 nucleus
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
196 GO:0005634 nucleus
201 GO:0005829 cytosol
201 GO:0005654 nucleoplasm
207 GO:0005829 cytosol
207 GO:0005654 nucleoplasm
287 GO:0005829 cytosol
287 GO:0043232 intracellular non-membrane-bounded organelle
287 GO:0031981 nuclear lumen
305 GO:0005634 nucleus
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
377 GO:0005634 nucleus
394 GO:0005654 nucleoplasm
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
420 GO:0005829 cytosol
420 GO:0005634 nucleus
463 GO:0005654 nucleoplasm
465 GO:0005654 nucleoplasm
469 GO:0043232 intracellular non-membrane-bounded organelle
469 GO:0005634 nucleus
475 GO:0070013 intracellular organelle lumen
475 GO:0005634 nucleus
522 GO:0005634 nucleus
526 GO:0005829 cytosol
526 GO:0031981 nuclear lumen
534 GO:0005829 cytosol
534 GO:0012505 endomembrane system
534 GO:0005654 nucleoplasm
544 GO:0005829 cytosol
544 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
671 GO:0005829 cytosol
671 GO:0070013 intracellular organelle lumen
671 GO:0005634 nucleus
728 GO:0005829 cytosol
728 GO:0005634 nucleus
758 GO:0005654 nucleoplasm
780 GO:0005654 nucleoplasm
823 GO:0005829 cytosol
823 GO:0005654 nucleoplasm
830 GO:0005856 cytoskeleton
830 GO:0005829 cytosol
830 GO:0070013 intracellular organelle lumen
830 GO:0005634 nucleus
837 GO:0005829 cytosol
837 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0000733 DNA strand renaturation IDA
GO:0006284 base-excision repair TAS
GO:0006289 nucleotide-excision repair IMP
GO:0006355 regulation of transcription, DNA-templated IDA
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0006461 protein complex assembly IDA
GO:0006914 autophagy IMP
GO:0006974 cellular response to DNA damage stimulus IDA
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
GO:0006983 ER overload response IDA
GO:0007050 cell cycle arrest IMP
GO:0007265 Ras protein signal transduction IEP
GO:0007275 multicellular organism development IMP
GO:0007569 cell aging IMP
GO:0008104 protein localization IDA
GO:0008283 cell proliferation TAS
GO:0008285 negative regulation of cell proliferation IDA
GO:0008340 determination of adult lifespan ISS
GO:0009299 mRNA transcription IMP
GO:0010165 response to X-ray IBA
GO:0010332 response to gamma radiation IMP
GO:0010628 positive regulation of gene expression IDA
GO:0016032 viral process IMP
GO:0016579 protein deubiquitination TAS
GO:0030154 cell differentiation TAS
GO:0030308 negative regulation of cell growth IMP
GO:0030330 DNA damage response, signal transduction by p53 class mediator IMP
GO:0031065 positive regulation of histone deacetylation IBA
GO:0031497 chromatin assembly IDA
GO:0031571 mitotic G1 DNA damage checkpoint IMP
GO:0032461 positive regulation of protein oligomerization IDA
GO:0034644 cellular response to UV IDA
GO:0035690 cellular response to drug IEP
GO:0042149 cellular response to glucose starvation IDA
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
GO:0042981 regulation of apoptotic process TAS
GO:0043065 positive regulation of apoptotic process IDA
GO:0043066 negative regulation of apoptotic process IMP
GO:0043153 entrainment of circadian clock by photoperiod ISS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0043525 positive regulation of neuron apoptotic process IBA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0046677 response to antibiotic IEP
GO:0046827 positive regulation of protein export from nucleus TAS
GO:0046902 regulation of mitochondrial membrane permeability TAS
GO:0048147 negative regulation of fibroblast proliferation IMP
GO:0048512 circadian behavior ISS
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
GO:0051097 negative regulation of helicase activity TAS
GO:0051262 protein tetramerization TAS
GO:0051289 protein homotetramerization IMP
GO:0051974 negative regulation of telomerase activity IDA
GO:0070245 positive regulation of thymocyte apoptotic process ISS
GO:0071158 positive regulation of cell cycle arrest IMP
GO:0071456 cellular response to hypoxia IEP
GO:0071479 cellular response to ionizing radiation IMP
GO:0071480 cellular response to gamma radiation IDA
GO:0072331 signal transduction by p53 class mediator IDA
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
GO:0072717 cellular response to actinomycin D IDA
GO:0090200 positive regulation of release of cytochrome c from mitochondria IDA
GO:0090399 replicative senescence IMP
GO:0090403 oxidative stress-induced premature senescence IMP
GO:0097193 intrinsic apoptotic signaling pathway TAS
GO:0097252 oligodendrocyte apoptotic process IDA
GO:1900119 positive regulation of execution phase of apoptosis IMP
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO:1902749 regulation of cell cycle G2/M phase transition TAS
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter IDA
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISS
GO:2000379 positive regulation of reactive oxygen species metabolic process IMP
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005622 intracellular IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005657 replication fork IBA
GO:0005669 transcription factor TFIID complex IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion IDA
GO:0005759 mitochondrial matrix IEA
GO:0005783 endoplasmic reticulum IEA
GO:0005829 cytosol TAS
GO:0016363 nuclear matrix IDA
GO:0016604 nuclear body IDA
GO:0016605 PML body IDA
GO:0043234 protein complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0000790 nuclear chromatin GO:0005783 endoplasmic reticulum 3.28e-06 8.79e-39
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005654 nucleoplasm GO:0005783 endoplasmic reticulum 1.84e-53 1.21e-118
GO:0005730 nucleolus GO:0005783 endoplasmic reticulum 1.07e-07 5.34e-56
GO:0005783 endoplasmic reticulum GO:0016604 nuclear body 2.68e-12 2.66e-147
Interactor Also a MoonDB EMF protein
FBLN4_HUMAN No
ASPP2_HUMAN No
CP135_HUMAN Yes: Q66GS9 (MoonDB)
CSK21_HUMAN Yes: P68400 (MoonDB)
ING4_HUMAN No
SMN_HUMAN No
WWOX_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
IKBA_HUMAN No
CDC42_HUMAN Yes: P60953 (MoonDB)
PP1G_HUMAN Yes: P36873 (MoonDB)
PP1A_HUMAN Yes: P62136 (MoonDB)
FTM_HUMAN No
UBE3A_HUMAN Yes: Q05086 (MoonDB)
PIN1_HUMAN No
HSPB1_HUMAN Yes: P04792 (MoonDB)
CE128_HUMAN Yes: Q6ZU80 (MoonDB)
SPICE_HUMAN Yes: Q8N0Z3 (MoonDB)
CE120_HUMAN Yes: Q8N960 (MoonDB)
NINL_HUMAN No
ARI2_HUMAN No
GRP75_HUMAN No
MLF2_HUMAN Yes: Q15773 (MoonDB)
HSP7C_HUMAN Yes: P11142 (MoonDB)
PLK1_HUMAN Yes: P53350 (MoonDB)
CSK2B_HUMAN Yes: P67870 (MoonDB)
AP2A_HUMAN No
1433E_HUMAN Yes: P62258 (MoonDB)
CE152_HUMAN No
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
AAKB2_HUMAN No
TYB4_HUMAN Yes: P62328 (MoonDB)
DAXX_HUMAN No
HS71A_HUMAN No
BAG2_HUMAN No
1433G_HUMAN No
1433S_HUMAN No
2A5G_HUMAN No
2AAA_HUMAN No
AIMP2_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
ANGT_HUMAN No
ANK2_HUMAN No
ANXA3_HUMAN No
ANXA7_HUMAN No
APOH_HUMAN No
ARL3_HUMAN No
ATF3_HUMAN No
ATR_HUMAN No
AURKA_HUMAN No
B2CL1_HUMAN No
BAG1_HUMAN No
BAX_HUMAN No
BCR_HUMAN No
BLM_HUMAN No
BMP1_HUMAN No
BRD7_HUMAN No
BTBD2_HUMAN No
CAPG_HUMAN No
CBP_HUMAN No
CC106_HUMAN No
CC14A_HUMAN No
CCL18_HUMAN No
CCNH_HUMAN No
CDK2_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
CDN2C_HUMAN No
CHD3_HUMAN Yes: Q12873 (MoonDB)
CHK1_HUMAN No
CHK2_HUMAN No
COX17_HUMAN No
CREB1_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
CSN5_HUMAN No
CUL7_HUMAN No
CUL9_HUMAN No
DNJC7_HUMAN No
DP13A_HUMAN Yes: Q9UKG1 (MoonDB)
DVL2_HUMAN No
E4F1_HUMAN No
EAF2_HUMAN No
ELL_HUMAN No
EP300_HUMAN Yes: Q09472 (MoonDB)
ERCC2_HUMAN No
ERH_HUMAN No
F173A_HUMAN No
FAK1_HUMAN No
FCAMR_HUMAN No
FOXO3_HUMAN No
FXYD6_HUMAN No
GA45A_HUMAN No
GPX2_HUMAN No
GSK3B_HUMAN No
GSTM4_HUMAN No
GUSP1_HUMAN No
HDAC1_HUMAN No
HDAC8_HUMAN No
HECD3_HUMAN No
HINFP_HUMAN No
HIPK1_HUMAN No
HIPK2_HUMAN No
HIPK3_HUMAN No
HMGB1_HUMAN No
HS71L_HUMAN No
HSP76_HUMAN No
IASPP_HUMAN No
IF2B_HUMAN No
IPYR_HUMAN No
IRF7_HUMAN No
K0087_HUMAN No
KAT2B_HUMAN No
KC1D_HUMAN No
KC1E_HUMAN No
KDM4D_HUMAN No
KITH_HUMAN No
KPCD_HUMAN No
LAMA4_HUMAN No
LEU1_HUMAN No
LMBL1_HUMAN No
MAGBI_HUMAN No
MAP9_HUMAN No
MAPK5_HUMAN No
MD2BP_HUMAN No
MDM2_HUMAN Yes: Q00987 (MoonDB)
MDM4_HUMAN Yes: O15151 (MoonDB)
MK01_HUMAN Yes: P28482 (MoonDB)
MK08_HUMAN No
MK11_HUMAN No
MK14_HUMAN No
MPH6_HUMAN No
MVP_HUMAN No
NCOA1_HUMAN No
NCOA2_HUMAN No
NCOR2_HUMAN No
NECD_HUMAN No
NIN_HUMAN No
NPM_HUMAN No
NR4A1_HUMAN Yes: P22736 (MoonDB)
NUCL_HUMAN No
OTUD5_HUMAN No
PA1B3_HUMAN No
PAR6B_HUMAN No
PARP1_HUMAN No
PCDA4_HUMAN No
PER2_HUMAN No
PIAS1_HUMAN No
PIAS2_HUMAN No
PIAS4_HUMAN No
PLCG2_HUMAN Yes: P16885 (MoonDB)
PML_HUMAN No
PNPH_HUMAN No
PSD11_HUMAN No
RAB4A_HUMAN Yes: P20338 (MoonDB)
RANB9_HUMAN No
RAP1B_HUMAN No
RCC1_HUMAN No
RFA1_HUMAN No
RN128_HUMAN No
RS10_HUMAN No
RS3_HUMAN No
RSMN_HUMAN No
S100B_HUMAN No
S10A1_HUMAN No
S10A2_HUMAN No
S10A4_HUMAN No
S10A6_HUMAN No
S10A8_HUMAN No
SAT1_HUMAN No
SCAM1_HUMAN No
SETD7_HUMAN No
SIN3B_HUMAN No
SMAD2_HUMAN No
SPB9_HUMAN No
SRPK1_HUMAN Yes: Q96SB4 (MoonDB)
ST1E1_HUMAN No
STAT6_HUMAN No
STK4_HUMAN No
STX5_HUMAN No
SUMO1_HUMAN Yes: P63165 (MoonDB)
T22D1_HUMAN No
T53G1_HUMAN No
TAF6_HUMAN No
TAF9_HUMAN No
TBP_HUMAN No
TCPE_HUMAN No
TCTP_HUMAN No
TDG_HUMAN No
TF2H1_HUMAN No
TF2H4_HUMAN No
THAP8_HUMAN No
TOP1_HUMAN No
TOPK_HUMAN No
TOPRS_HUMAN No
TP53B_HUMAN No
TWST1_HUMAN No
UBC9_HUMAN Yes: P63279 (MoonDB)
UBE2A_HUMAN No
UBE2K_HUMAN Yes: P61086 (MoonDB)
UBP7_HUMAN No
UFD1_HUMAN Yes: Q92890 (MoonDB)
UHRF2_HUMAN No
WDR33_HUMAN No
WRN_HUMAN No
ZCH10_HUMAN No
ZHX1_HUMAN No
ZMIZ1_HUMAN No
ZMIZ2_HUMAN No
ZN302_HUMAN No
ZN363_HUMAN No
ZNF24_HUMAN No
PMID Article Title
1303181 A novel mutation in the p53 gene in a Burkitt's lymphoma cell line.
1327751 Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.
1394225 Frequent p53 mutations in head and neck cancer.
1437144 p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas.
1459726 The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.
1565144 Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
1631151 An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.
1647768 Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.
1672732 Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa.
1694291 Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.
1699228 p53 mutations in colorectal cancer.
1705009 The tumor suppressor p53 is bound to RNA by a stable covalent linkage.
1737852 Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
1848668 Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.
1849234 Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
1868473 p53 gene mutations in Barrett's epithelium and esophageal cancer.
1905840 p53 mutations in human cancers.
1915267 p53 is frequently mutated in Burkitt's lymphoma cell lines.
1933902 A germ line mutation in exon 5 of the p53 gene in an extended cancer family.
1978757 Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
1999338 Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.
2141171 Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.
2156209 The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.
2259385 Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.
2263646 Frequent mutation of the p53 gene in human esophageal cancer.
2905688 A variation in the structure of the protein-coding region of the human p53 gene.
2946935 Characterization of the human p53 gene.
3025664 Molecular basis for heterogeneity of the human p53 protein.
3894933 Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.
4006916 Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.
6396087 Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene.
7682763 p53 alterations in human squamous cell carcinomas and carcinoma cell lines.
7773777 Solution structure of the tetrameric minimum transforming domain of p53.
7878469 Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.
7887414 Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.
8013454 A temperature-sensitive mutant of human p53.
8023157 Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
8023159 High-resolution structure of the oligomerization domain of p53 by multidimensional NMR.
8118819 Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.
8266092 p53: at the crossroads of molecular carcinogenesis and risk assessment.
8316628 Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs.
8336944 Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors.
8402617 The incidence of p53 mutations increases with progression of head and neck cancer.
8632903 The human tumour suppressor gene p53 is alternatively spliced in normal cells.
8632915 Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.
8718514 Germline mutations in the TP53 gene.
8825920 An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.
8829627 Molecular analysis of the TP53 gene in Barrett's adenocarcinoma.
8829653 Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses.
8875926 Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
9101296 Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer.
9321402 Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.
9372954 p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
9419979 Drastic genetic instability of tumors and normal tissues in Turcot syndrome.
9450901 Detection of p53 gene mutations in oral squamous cell carcinomas of a black African population sample.
9452042 A germline missense mutation R337C in exon 10 of the human p53 gene.
9840937 Regulation of CAK kinase activity by p53.
10484981 Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.
10549356 p53 and human cancer: the first ten thousand mutations.
10551826 A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain.
10570149 Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.
10606744 Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.
10644996 p53 is involved in the p120E4F-mediated growth arrest.
10656795 Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry.
10722742 Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
10884347 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
10951572 The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.
11007800 p53 amino acids 339-346 represent the minimal p53 repression domain.
11023613 Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.
11025664 The function of PML in p53-dependent apoptosis.
11058590 Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity.
11124955 SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting.
11239457 A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
11447225 Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.
11481490 An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.
11546806 Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.
11551930 Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
11554448 Zinc binding and redox control of p53 structure and function.
11554766 Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.
11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
11706030 Differential effect of ik3-1/cables on p53- and p73-induced cell death.
11740489 Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.
11780126 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
11925430 Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.
12085209 Investigations on a clinically and functionally unusual and novel germline p53 mutation.
12507430 Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.
12702766 Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
12724314 Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.
12750254 p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
12810724 The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.
12851404 TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.
12944468 Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination.
14534297 Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.
14660794 Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14702041 Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.
15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.
15053880 A dynamic role of HAUSP in the p53-Mdm2 pathway.
15109303 Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.
15136035 The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.
15186775 Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.
15340061 Regulation of human p53 activity and cell localization by alternative splicing.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15525938 Regulation of p53 activity through lysine methylation.
15701641 Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.
15855171 Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
15866171 AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
16131611 p53 isoforms can regulate p53 transcriptional activity.
16219768 WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
16376338 Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
16377624 Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
16402859 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
16415881 Structural basis for the methylation site specificity of SET7/9.
16474402 Molecular recognition of p53 and MDM2 by USP7/HAUSP.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16704422 The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.
16793544 Structural basis of DNA recognition by p53 tetramers.
16845383 Critical role for Daxx in regulating Mdm2.
16959974 The consensus coding sequences of human breast and colorectal cancers.
17015838 Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.
17108107 LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.
17108971 Repression of p53 activity by Smyd2-mediated methylation.
17121812 CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
17170702 Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
17224074 Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.
17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
17254968 PRAK is essential for ras-induced senescence and tumor suppression.
17311302 Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.
17317671 The notch regulator MAML1 interacts with p53 and functions as a coactivator.
17332504 Dynamic regulation of p53 subnuclear localization and senescence by MORC3.
17349958 DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.
17467953 Nine-amino-acid transactivation domain: establishment and prediction utilities.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17591690 Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.
17707234 Modulation of p53 function by SET8-mediated methylation at lysine 382.
17719541 Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.
17805299 p53 is regulated by the lysine demethylase LSD1.
17904127 SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
17967874 Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.
18022393 Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9.
18206965 Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.
18249187 Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.
18453682 Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution.
18585004 Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes.
18650397 Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
18996393 Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19473992 Plk1-mediated phosphorylation of Topors regulates p53 stability.
19509332 JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.
19515728 Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.
19536131 Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.
19556538 Trim24 targets endogenous p53 for degradation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19776115 Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein.
19837670 MTA1 coregulator regulates p53 stability and function.
19880522 Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.
20041275 Isoform specific phosphorylation of p53 by protein kinase CK1.
20096447 USP10 regulates p53 localization and stability by deubiquitinating p53.
20118233 G9a and Glp methylate lysine 373 in the tumor suppressor p53.
20124405 G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.
20142040 Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant.
20173098 RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
20228809 BRD7 is a candidate tumour suppressor gene required for p53 function.
20364130 Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
20385133 p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.
20660729 Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
20673990 A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.
20870725 The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.
20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
21269460 Initial characterization of the human central proteome.
21317932 A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.
21946351 A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
21952639 NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
22214662 The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest.
22522597 Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.
22726440 p53 opens the mitochondrial permeability transition pore to trigger necrosis.
22864287 PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
22945289 ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis.
23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
24051492 p53 regulates Period2 expression and the circadian clock.
25422469 Disruption of FAT10-MAD2 binding inhibits tumor progression.
25591766 RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.
25732823 DBC1 functions as a tumor suppressor by regulating p53 stability.
25772236 PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
27323408 LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.
OMIM ID Disease Name
133239 Esophageal cancer
151623 Li-Fraumeni syndrome
202300 Adrenocortical carcinoma
211980 Lung cancer
260500 Papilloma of choroid plexus
Domain Name Domain ID Source
DNHU53 A25224 PIR
p53_tumour_suppressor IPR002117 InterPro
p53-like_TF_DNA-bd IPR008967 InterPro
p53_tetrameristn IPR010991 InterPro
p53_DNA-bd IPR011615 InterPro
p53/RUNT-type_TF_DNA-bd_sf IPR012346 InterPro
p53_transactivation_domain IPR013872 InterPro
p53_tetramer_sf IPR036674 InterPro
P53 PF00870 Pfam
P53_tetramer PF07710 Pfam
P53_TAD PF08563 Pfam
P53SUPPRESSR PR00386 PRINTS
P53 PS00348 PROSITE
PTHR11447 PTHR11447 PANTHER
SSF47719 SSF47719 SUPFAM
SSF49417 SSF49417 SUPFAM
P53 cd08367 CDD